Molecular Subtype Specific Therapy in High Grade Serous Ovarian Cancer

Grant number: 1081178 | Funding period: 2015 - 2017

Completed

Abstract

High grade serous ovarian cancer (HGSC) is the most common type of ovarian cancer, accounting for about two thirds of all deaths from the disease.Several years ago we identified distinct subtypes of HGSC (C1, C2, C4, C5) based on patterns of gene activity. We found that women with the C5 subtype generally had poor survival, and we mapped genes that were specifically active in C5 tumours. In this application we aim to develop therapies that are specifically targeted to the C5 HGSC.

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The microtubule inhibitor eribulin demonstrates efficacy in platinum-resistant and refractory high-grade serous ovarian cancer patient-derived xenograft models

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The FZD7-TWIST1 axis is responsible for anoikis resistance and tumorigenesis in ovarian carcinoma

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Frizzled family receptor 7 (FZD7), a Wnt signaling receptor, is associated with the maintenance of stem cell properties and cancer..

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Global practices in PDX programs

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Patient-derived xenograft (PDX) programs are crucial research tools in providing high-quality preclinical data for successful drug..

University of Melbourne Researchers